Experimental beneficial effect of rosuvastatin on burn wound healing in a rat model

Figure 3 Representative microscopic burn wound healing images. A: Coagulative necrosis involving the epidermis and superficial dermis, characterized by loss of tissue architecture and magenta staining (arrowheads). Control group, day 9; haematoxylin-eosin (HE) staining, magnification × 40; B: Focal coagulative necrosis observed in skin tissue (arrowheads). Rosuvastatin group, day 9; HE staining, magnification × 40; C: Scant neoplastic capillaries (arrow) corresponding to a low vascular score) observed in a healing area, control group, day 9; HE staining, magnification × 200; D: Highly vascularized connective tissue (arrows) corresponding to a high vascular score, rosuvastatin group, day 9; HE staining, magnification × 20; E: Granulation tissue showing mild to moderate inflammatory cell infiltration (score 1), rosuvastatin group, day 9; HE staining, magnification × 200; F: Granulation tissue showing severe inflammatory cell infiltration (score 2), placebo group, day 9; HE staining, magnification × 200; G: Mild fibroblastic response with moderate fibroblast proliferation and minimal collagen deposition, control group, day 9; HE staining, magnification × 200; H: Marked fibroblastic reaction with extensive fibroblast proliferation and increased collagen deposition, rosuvastatin group, day 9; HE staining, magnification × 100; I: Μicrohemorrhage (small, well-defined area of extravasated red blood cells), placebo group, day 9; HE staining, magnification × 100; J: Multifocal scattered microhemorrhages (small foci of red blood cell extravasation), rosuvastatin group, day 9; HE staining, magnification × 100.