Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs

doi:10.5493/wjem.v16.i1.112270

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Exp Med. Mar 20, 2026; 16(1): 112270
Published online Mar 20, 2026. doi: 10.5493/wjem.v16.i1.112270

Table 1 Multiparametric echocardiographic score for the diagnosis of Cardiac amyloidosis

Echocardiographic parameter	Diagnostic threshold	Score
Relative LV wall thickness (IVS + PWT)/LVEDD	> 0.6	3 points
E/e’ ratio (Doppler E wave to e’ velocity)	> 11	1 point
Tricuspid annular plane systolic excursion	≤ 19 mm	2 points
LV global longitudinal strain absolute value	≤ -13%	1 point
Systolic longitudinal strain apex-to-base ratio	> 2.9	3 points

IVS: Interventricular septal wall thickness; PWT: Posterior wall thickness; LVEDD: Left ventricular end-diastolic diameter; LV: Left ventricular.

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Citation: Bouziane M, Moufid O, Habbal R. Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs. World J Exp Med 2026; 16(1): 112270
URL: https://www.wjgnet.com/2220-315x/full/v16/i1/112270.htm
DOI: https://dx.doi.org/10.5493/wjem.v16.i1.112270

Bouziane M, Moufid O, Habbal R. Cardiac amyloidosis: From diagnosis to therapeutics breakthroughs. World J Exp Med 2026; 16(1): 112270 [PMID: 41883450 DOI: 10.5493/wjem.v16.i1.112270]

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