Synthetic messenger RNA vaccines and transcriptomic dysregulation: Evidence from new-onset adverse events and cancers post-vaccination

Figure 3 Protein-protein interaction network of the most dysregulated genes in group 2. A: Genes related to transcriptomic instability, translational stress; B: Genes related to genomic instability and epigenetic shift; C: Genes associated with endothelial dysfunction; D: Genes related to systemic inflammatory and immune response; E: Genes that are related to proliferative signaling and suppressed tumor control. Group 2 includes patients with new-onset cancers diagnosed shortly after messenger RNA coronavirus disease 2019 vaccination (n = 7), compared with normal controls (n = 803 unvaccinated individuals from the GTEx dataset). Node color intensity reflects the degree of interaction (connectivity), with darker nodes indicating higher connectivity or a hub status within the network.