Synthetic messenger RNA vaccines and transcriptomic dysregulation: Evidence from new-onset adverse events and cancers post-vaccination

Figure 2 Protein-protein interaction network of the most dysregulated genes in group 1. A: Genes related to proliferative signaling and tumor control; B: Genes related to systemic inflammatory immune; C: Genes related to transcriptomic instability; D: Genes related to mitochondrial electron transport dysfunction and reactive oxygen species; E: Genes related to proteasome-mediated protein degradation stress. Group 1 includes patients with new-onset adverse events following messenger RNA coronavirus disease 2019 vaccination (n = 3), compared with normal controls (n = 803 unvaccinated individuals from the GTEx dataset). Node color intensity reflects the degree of interaction (connectivity), with darker nodes indicating higher connectivity or a hub status within the network.