Sacubitril/valsartan as add-on to standard therapy in patients with heart failure: A randomized controlled trial

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

World J Exp Med. Dec 20, 2025; 15(4): 111542
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.111542

Table 2 Biochemical parameters at 0 and 12 weeks in the two study groups

Parameter	Study group	0 week	12 weeks	P value
N-terminal pro-B-type natriuretic peptide (pg/mL)	Group A	117.54 ± 38.50	81.63 ± 31.17	< 0.0001^a
N-terminal pro-B-type natriuretic peptide (pg/mL)	Group B	97.37 ± 31.18	122.05 ± 42.96	0.0007^a
High-sensitivity C-reactive protein levels (mg/L)	Group A	6.25 ± 4.14	3.38 ± 3.68	< 0.0001^a
High-sensitivity C-reactive protein levels (mg/L)	Group B	5.64 ± 3.83	6.40 ± 3.76	0.0007^a

^aP < 0.05.

Citation: Dhawan R, Mittal R, Kumar A, Laller KS, Gill PS, Rag A, Mittal N. Sacubitril/valsartan as add-on to standard therapy in patients with heart failure: A randomized controlled trial. World J Exp Med 2025; 15(4): 111542
URL: https://www.wjgnet.com/2220-315x/full/v15/i4/111542.htm
DOI: https://dx.doi.org/10.5493/wjem.v15.i4.111542

Dhawan R, Mittal R, Kumar A, Laller KS, Gill PS, Rag A, Mittal N. Sacubitril/valsartan as add-on to standard therapy in patients with heart failure: A randomized controlled trial. World J Exp Med 2025; 15(4): 111542 [PMID: 41497676 DOI: 10.5493/wjem.v15.i4.111542]

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