Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant

Table 6 Results of the univariate and multivariate analyses

Breast cancer characteristics	Univariate analysis		Multivariate analysis
	OR (95%CI)	P value	OR (95%CI)	P value
N stage		0.017a
N0	-		-
N1	1.62 (0.75-3.48)	0.217	1.64 (0.63-35.39)	0.303
N2-3	6.18 (1.34-28.47)	0.019a	5.45 (0.83-35.73)	0.077
Tumor grade		< 0.0000a
G3	-		-
G1-2	12.62 (5.40-29.56)	< 0.0000a	4.54 (1.59-12.95)	0.0057a
Estrogen receptor status		0.0001a
≤ 80%	-
> 80%	7.52 (2.71-20.82)	< 0.0000a	2.57 (0.69-9.62)	0.16
Progesterone receptor status		0.0000a
< 30%	-
≥ 30%	6.67 (3.11-14.28)	< 0.0000a	5.77 (2.09-15.97)	0.001a
HER2 status		< 0.0000a
HER2 0 and +	-		-
HER2 ++ and +++	8.54 (3.61-20.21)	< 0.0000a	3.51 (1.17-10.47)	0.024
PNI		0.044a
No	-
Yes	2.69 (1.03-7.03)	0.032a	2.41 (0.73-7.89)	0.14
Lack of cPDCD1 LG1 in TCs		< 0.0000a
≥ 20%	-		-
< 20%	12.52 (5.50-28.50)	< 0.0000a
PDCD1 LG1 IC score
≥ 10%	-
< 10%	1.50 (0.59-3.84)	0.03977
Combination of PDCD1 LG1+ IC score and lack of cPDCD1 LG1 in TCs		0.0001a
Lack of cPDCD1 LG1 in ≥ 20% of the TCs and PDCD1 LG1 IC scores ≥ 10%	-		-
Lack of cPDCD1 LG1 in ≥ 20% of the TCs and PDCD1 LG1 IC scores < 10%	3.11 (0.94-10.25)	0.06a	1.51 (0.30-7.49)	0.616
Lack of cPDCD1 LG1 in < 20% of the TCs and PDCD1 LG1 IC scores ≥ 10%	2.49 (0.87-0.09)	0.09a	1.82 (0.45-7.37)	0.399
Lack of cPDCD1 LG1 in < 20% of the TCs and PDCD1 LG1 IC scores < 10%	12.00 (3.70-38.90)	< 0.0000a	7.59 (1.63-4.24)	0.01a

^aP < 0.05 was considered statistically significant.

ICs: Immune cells; PNI: Perineural invasion; TCs: Tumor cells; cPDCD1 LG1: Cytoplasmic programmed cell death protein 1 ligand 1.