Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant

doi:10.5493/wjem.v15.i4.110890

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Dec 20, 2025; 15(4): 110890
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.110890

Table 5 Results of the correlation analysis

Breast cancer characteristics	Correlation coefficient	P value
Т stage¹	-0.103	0.40932
N stage¹	-0.385	0.00302^a
Clinical stage¹	-0.079	0.15234
Tumor grade¹	0.874	0.00000^a
Estrogen receptor status¹	-0.988	0.00000^a
Progesterone receptor status¹	-0.540	0.00004^a
HER2 status¹	0.978	0.00000^a
Ki67 index²	0.861	0.00000^a
Lymphovascular invasion¹	0.094	0.51440
Perineural invasion¹	-0.515	0.00199^a
Intraductal component¹	0.114	0.54373
сPDCD1 LG1 expression in TCs¹	0.081	0.42558
Lack of cPDCD1 LG1 in TCs¹	0.432	0.00000^a
PDCD1 LG1+ IC score¹	0.454	0.00000^a

¹Kendall rank correlations.

²Spearman Rank Order Correlations.

^aP < 0.05 was considered statistically significant.

ER: Estrogen receptors; HER2: Human epidermal growth factor receptor 2; ICs: Immune cells; TCs: Tumor cells; TNBC: Triple negative breast cancer; cPDCD1 LG1: Cytoplasmic programmed cell death protein 1 ligand 1.

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Citation: Senchukova MA, Zubareva EY, Saidler NV, Krivolapova LV. Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant. World J Exp Med 2025; 15(4): 110890
URL: https://www.wjgnet.com/2220-315x/full/v15/i4/110890.htm
DOI: https://dx.doi.org/10.5493/wjem.v15.i4.110890

Senchukova MA, Zubareva EY, Saidler NV, Krivolapova LV. Lack of cytoplasmic expression of a new marker programmed cell death ligand-1 in tumor cells is significant. World J Exp Med 2025; 15(4): 110890 [PMID: 41497695 DOI: 10.5493/wjem.v15.i4.110890]

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