Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma

doi:10.5493/wjem.v15.i4.110372

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World Journal of Experimental Medicine

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2220-315x

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Dec 20, 2025; 15(4): 110372
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.110372

Table 4 Univariate comparison of different immunohistochemical parameters (variables) in oral epithelial dysplasia and oral squamous cell carcinoma groups (χ² test)

Variables	OED	%	OSCC	%	Total	%	χ²	P value
E-Cad intensity	18	60.00	19	63.33	37	61.67	0.0710	0.7910
E-Cad location	8	26.67	25	83.33	33	55.00	19.4610	0.0001^b
E-Cad percentage	25	83.33	15	50.00	40	66.67	7.5000	0.0060^b
ZEB1 EPI intensity	9	30.00	11	36.67	20	33.33	0.3000	0.5840
ZEB1 EPI location	8	26.67	1	3.33	9	15.00	9.2310	0.0020^b
ZEB1 EPI percentage	18	60.00	23	76.67	41	68.33	1.9260	0.1650
ZEB1 CT intensity	28	93.33	15	50.00	43	71.67	13.8710	0.0001^b
ZEB1 CT percentage	23	76.67	6	20.00	29	48.33	19.2880	0.0001^b

^bP < 0.01.

ZEB1: Zinc-finger E-box-binding homeobox 1; EPI: Epithelium; CT: Connective tissue; OED: Oral epithelial dysplasia; OSCC: Oral squamous cell carcinoma.

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Citation: Panchannavar GS, Angadi PV. Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma. World J Exp Med 2025; 15(4): 110372
URL: https://www.wjgnet.com/2220-315x/full/v15/i4/110372.htm
DOI: https://dx.doi.org/10.5493/wjem.v15.i4.110372

Panchannavar GS, Angadi PV. Immunohistochemical expression of epithelial mesenchymal transition proteins ZEB1 and E-cadherin in oral leukoplakia and oral squamous cell carcinoma. World J Exp Med 2025; 15(4): 110372 [PMID: 41497688 DOI: 10.5493/wjem.v15.i4.110372]

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