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World J Exp Med. Dec 20, 2025; 15(4): 108221
Published online Dec 20, 2025. doi: 10.5493/wjem.v15.i4.108221
Figure 1
Figure 1 Schematic diagram of chromosome 11 and its short (p) arm-linked certain diseases. Aniridia: A pan-ocular disorder with partial or complete deficiency of the iris; Beckwith-Wiedemann syndrome: A congenital overgrowth disorder; Beta-hemoglobinopathies (defects in β-globin chains): Beta-thalassemia and Sickle cell disease; Congenital hyperinsulinism: Characterized by excess insulin secretion and profound hypoglycemia; Denys-Drash syndrome: A disorder with congenital nephropathy/diffuse glomerulosclerosis, Wilms tumor, gonadal dysgenesis and cryptorchidism (among male patients); Frasier syndrome: Associated with nephropathy/focal segmental glomerulosclerosis, and gonadal abnormalities that commonly become cancerous/gonadoblastoma (among male patients); Silver-Russell syndrome: Clinical features include growth restriction, body asymmetry, and relative macrocephaly (etiologies are not related to chromosome 11 in about 50% of cases); WAGR: Wilms tumor-aniridia-genitourinary abnormalities-mental retardation.


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