Integrative review of the gut microbiome’s role in pain management for orthopaedic conditions

Table 1 Gut microbiome in orthopedic conditions

Ref.	Orthopedic condition	Key findings on microbiome composition	Main conclusion
Liu et al[50], 2021	Sarcopenia	Decreased lactobacillus and bifidobacterium	Correlation between microbiome and muscle mass
Chakraborty et al[51], 2022	Coronavirus disease	Elevated gut microbes such as Rothia mucilaginosa, Granulicatella spp, Collinsella tanakaei, Collinsella aerofaciens, Morganella morganii, and Streptococcus infantis	Correlation between microbiome and inflammation
Collins et al[52], 2017	Post menopausal osteoporosis	Lactobacillus, Enterococcus, Bacillus, Escherichia, and Bifidobacterium	Improvement in condition by supplementation
Ramires et al[53], 2022	Osteoarthritis	Lower proportion of Bacteroidetes and higher Firmicutes bacterial populations	Correlation between microbiome and bone mass