Platelet-to-neutrophil ratio predicts hemorrhagic transformation and unfavorable outcomes in acute ischemic stroke with intravenous thrombolysis

Table 1 Clinical characteristics of the study population

Characteristics	Number
Age in yr	64.5 (53-72)
Sex
Male	249 (59.6)
Female	169 (40.4)
Risk factor
Hypertension	299 (71.5)
Dyslipidemia	276 (66)
Diabetes mellitus	141 (33.7)
Atrial fibrillation/atrial flutter	102 (24.4)
Old stroke	47 (11.2)
Current smoking	73 (17.5)
Current alcohol drinking	42 (10)
Etiology
Other determined or undetermined	177 (42.3)
Cardioembolic	102 (24.4)
Small-artery occlusion	94 (22.5)
Large-artery atherosclerosis	42 (10)
Medication before stroke onset
Antihypertensive therapy	202 (48.3)
Antiplatelet therapy	81 (18.3)
Hypoglycemic therapy	121 (27.3)
Time for stroke onset to intravenous rtPA infusion in min	170.05 (124-218.25)
Infarct volume in mL	3.27 (0.58-24.24)
Hemorrhagic transformation
No	343 (82)
Yes	75 (82)
PH1	29 (82)
PH2	27 (6.1)
HI1	12 (2.7)
HI2	7 (1.6)

Data are n (%)/median (25^th-75^th percentiles). HI: Hemorrhagic infarct; PH: Parenchymal hemorrhage; rtPA: Recombinant tissue plasminogen activator.