Predictors of disease recurrence after radical resection and adjuvant chemotherapy in patients with stage IIb-IIIa squamous cell lung cancer: A retrospective analysis

Table 3 Univariate and multifactorial logistic regression analysis

Characteristic	Univariate analysis OR (95%CI)	P value	Multivariate analysis OR (95%CI)	P value
Age (yr)
< 60	1	-
60-69	1.60 (0.51-5.02)	0.420
≥ 70	1.24 (0.25-6.17)	0.789
Tumor localization
Peripheral	1	-
Central	3.07 (0.85-11.07)	0.089
Histology
KSCC	1	-
NKSCC	2.60 (0.84-8.07)	0.101
Grade
G1	1	-	1	-
G2	0.59 (0.13-2.54)	0.590	0.91 (0.44-4.56)	0.345
G3	6.00 (1.01-67.28)	0.0211	7.94 (1.08-135.81)	0.0481
T stage
T1b	1	-
T2a	1.62 (0.25-10.36)	0.622
T2b	0.80 (0.08-8.47)	0.853
T3	0.63 (0.10-3.95)	0.631
N stage
N0	1	-	1	-
N1	5.63 (1.27-24.86)	0.0231	5.67 (1.09-36.54)	0.0481
N2	3.75 (0.77-18.21)	0.101	6.30 (0.78-50.78)	0.08
Stage
IIb	1	-
IIIa	1.44 (0.50-4.14)	0.498
DCs of “contact type”
Presence	1	-
Absence	1.61 (0.53-4.91)	0.404
The capillaries in the tumor solid component
Absence	1	-
Presence	2.24 (0.74-6.79)	0.154
LFFCT in the tumor stroma
Absence	1	-	1	-
Presence	15.33 (3.56-66.04)	0.00021	21.70 (4.27-110.38)	0.00021
Fragmentation in the tumor solid component
Absence	1	-	1	-
Presence	3.42 (1.06-11.03)	0.0401	2.53 (1.01-12.23)	0.0491
Peritumoral retraction clefting
Absence	1	-
Presence	0.41 (0.13-1.30)	0.13
Tumor spread in the AAS
Absence	1	-
Presence	1.08 (0.38-3.07)	0.883

¹The differences between groups are statistically significant, P < 0.05.

AAS: Alveolar air spaces; DCs: Dilated capillaries; KSCC: Keratinizing squamous cell carcinoma; LFFCT: Loose, fine-fiber connective tissue in the tumor stroma; NKSCC: Nonkeratinizing squamous cell carcinoma.