Review
Copyright ©The Author(s) 2015.
World J Exp Med. May 20, 2015; 5(2): 40-49
Published online May 20, 2015. doi: 10.5493/wjem.v5.i2.40
Table 1 EC-derived factors related to organogenesis
Angiocrine factorsSourceTargetRef
Notch ligands (1 and 2)Bone marrow ECs; brain ECsNeural progenitors and HSCs[40,41]
VEGFECsECs and several tissues such as islets[12,42,43]
bFGFECsECs and several tissues such as islets[43]
PDGFBrain capillariesECs[42]
HGFLunga capillaries, SECs,Lung epithelium, hepatocytes, islet beta cells[26,31,44,45]
islet capillaries
EndothelinsECsLung, neural cells[46]
EG-VEGFECsEndocrine glands[32]
Brain-derived neurotrophic factorBrain microvascular endotheliumNeuronal precursors,[33]
islet endothelium
Pigment epithelium-derived factorBrain capillariesNeural stem cells[35,47]
Vessel-derived stromal-derived factor 1 (SDF-1/CXCL12)Microvascular endotheliumEndoderm and pancreatic beta cells[48]
Wnt2Sinusoidal ECsHepatocytes[26]
S1PPlasma (plateles)Pancreatic multipotent progenitor cells[38]
CTGFPancreas capillariesPancreatic endocrine cells[49]
LamininIslet capillariesIslet endocrine cells[50]
Collagen IVIslet capillariesIslet beta-cells[51]
BMP-2ECs/MSCsIslet beta-cells[52,53]
BMP-4ECs/MSCsIslet beta-cells; hepatocytes; cardiomyocytes[52,53]
BMPR1AECs/MSCsIslet beta-cells; hepatocytes; cardiomyocytes[52,53]