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World J Exp Med. Nov 20, 2014; 4(4): 46-57
Published online Nov 20, 2014. doi: 10.5493/wjem.v4.i4.46
Published online Nov 20, 2014. doi: 10.5493/wjem.v4.i4.46
Figure 1 “Vicious cycle” of reactive oxygen species production, mitochondrial DNA damage, mitochondrial DNA mutagenesis and further reactive oxygen species production.
The cycle implies an exponential growth of reactive oxygen species (ROS) production and mitochondrial DNA (mtDNA) mutagenesis.
- Citation: Shokolenko IN, Wilson GL, Alexeyev MF. Aging: A mitochondrial DNA perspective, critical analysis and an update. World J Exp Med 2014; 4(4): 46-57
- URL: https://www.wjgnet.com/2220-315X/full/v4/i4/46.htm
- DOI: https://dx.doi.org/10.5493/wjem.v4.i4.46