Multiple sclerosis and the role of immune cells

Table 1 Chemokines receptor expression on T cells and T cell clones isolated from MS patient

Receptor	Main role	Ligands	CD4+ subsets			PBL-74		PBL-78		CSF-25		CSF-26
			Th1	Th2	Naive	Unact	Act	Unact	Act	Unact	Act	Unact	Act
CXC family
CXCR1	I	CXCL6, CXCL7, CXCL8
CXCR2	I	CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, CXCL8
CXCR3	I	CXCL9, CXCL10, CXCL11	H			H	M	H	M	H	M	H	L
CXCR4	C	CXCL12			H
CXCR5	C	CXCL13		M
CXCR6	I	CXCL16
CXCR7	D	CXCL11, CXCL12
CC family
CCR1	I	CCL3, CCL5, CCL7, CCL8, CCL15, CCL16, CCL23	M
CCR2	I	CCL2, CCL7, CCL8, CCL13, CCL16	H	H
CCR3	I	CCL5 ,CCL7, CCL11, CCL13, CCL15, CCL24, CCL26, CCL28		H
CCR4	D	CCL17, CCL22		H		H	H	H	M	H	H	L
CCR5	I	CCL3, CCL4, CCL5, CCL8, CCL11, CCL14, CCL16	H			H	M	L		H	M
CCR6	D	CCL20				M		M		L
CCR7	C	CCL19, CCL21			H
CCR8	I	CCL1, CCL16		H
CCR9	D	CCL25,
CCR10	I	CCL27, CCL28						L	L
Other
XCR1	I	XCL1, XCL2
CX3CR1	D	CX3CL1

Data adapted from Høglund et al[53], Maghazachi[90], Zlotnik et al[117] and Sallusto et al[118] . I: Inflammatory; C: Constitutive; D: Dual activities; Unact: Unactivated; Act: Activated; PBL: Peripheral blood lymphocytes; CSF: Cerebrospinal fluid. H: High expression; M: Medium expression; L: Low expression.