Changes in the metabolism of axillary lymph node cells as a predictor of regional metastasis in breast cancer

Table 2 Evaluation of vascular cell adhesion molecule-1 and C-X-C motif chemokine receptor 4 expression in axillary lymph nodes

	VCAM-1	CXCR4
Marker expression in the LN sinuses
The number of sinuses	0: None
	1: ≤ 15%
	2: > 15%
The intensity of marker expression	0: No expression	0: No expression
	1: Weak expression	1: Expression present
	2: Moderate expression
	3: Pronounced expression
Marker expression scores in LN sinuses	By multiplying the number of sinuses and intensity of marker expression (score range 0-6)	By multiplying the number of sinuses and intensity of marker expression (score range 0-2)
Marker expression in the LN follicles
Number of follicles	0: < 5% of the lymph node area
	1: ≥ 5% and < 30% of the lymph node area
	2: ≥ 30% of the lymph node area
The intensity of marker expression	0: No expression	0: No expression
	1: Weak expression	1: Weak expression
	2: Moderate expression	2: Moderate expression
	3: Pronounced expression	3: Pronounced expression
Marker expression scores in LN follicles	By multiplying the number of follicles and intensity of marker expression (score range 0-6)	By multiplying the number of follicles and intensity of marker expression (score range 0-6)
Marker expression in the LN cortex
The intensity of marker expression	0: No expression	0: No expression
	1: Weak expression	1: Weak expression
	2: Moderate expression	2: Moderate expression
Marker expression in the LN medulla
The intensity of marker expression	0: No expression	0: No expression
	1: Weak expression	1: Weak expression
	2: Moderate expression	2: Moderate expression
Marker expression in metastases cells
Number of cells with marker expression	1: < 50% of cells	1: < 50% of cells
	2: 50% or more of cells	2: 50% or more of cells
The intensity of marker expression	0: No expression	0: No expression
	1: Weak expression	1: Weak expression
	2: Moderate expression	2: Moderate expression
	3: Pronounced expression
Marker expression scores in metastases	By multiplying the number of cells with marker expression and intensity of marker expression (score range 0-4)	By multiplying the number of cells with marker expression and intensity of marker expression (score range 0-4)

CXCR4: C-X-C motif chemokine receptor 4; LN: Lymph node; VCAM: Vascular cell adhesion molecule-1.