Changes in the metabolism of axillary lymph node cells as a predictor of regional metastasis in breast cancer

doi:10.5493/wjem.125128

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World Journal of Experimental Medicine

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2220-315X

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World J Exp Med. Sep 20, 2026; 16(3): 125128
Published online Sep 20, 2026. doi: 10.5493/wjem.125128

Table 10 Correlations of C-X-C motif chemokine receptor 4 expression with the clinical and pathological characteristics of patients with breast cancer

	Spearman-R	t(N-2)	P value
Age
CXCR4 expression in the LN sinuses	-0.033856	-0.28744	0.77460
CXCR4 expression in the LN follicles	0.186206	1.60813	0.11218
CXCR4 expression in the LN cortex	0.264398	2.32627	0.02282^a
CXCR4 expression in the LN medulla	0.152145	1.30620	0.19564
T stage
CXCR4 expression in the LN sinuses	-0.363676	-3.31274	0.00145^a
CXCR4 expression in the LN follicles	-0.201267	-1.74349	0.08552
CXCR4 expression in the LN cortex	-0.242079	-2.11708	0.03771
CXCR4 expression in the LN medulla	-0.026276	-0.22303	0.82414
N stage
CXCR4 expression in the LN sinuses	0.109123	0.93150	0.35471
CXCR4 expression in the LN follicles	0.587228	6.15600	<0.00001^a
CXCR4 expression in the LN cortex	-0.045038	-0.38255	0.70318
CXCR4 expression in the LN medulla	0.412394	3.84111	0.00026^a
Tumor grade (G)
CXCR4 expression in the LN sinuses	0.210901	1.83073	0.07128
CXCR4 expression in the LN follicles	-0.037919	-0.32199	0.74840
CXCR4 expression in the LN cortex	0.356227	3.23489	0.00184^a
CXCR4 expression in the LN medulla	-0.063014	-0.53575	0.59378
Lymphovascular invasion
CXCR4 expression in the LN sinuses	0.007235	0.06139	0.95122
CXCR4 expression in the LN follicles	0.295087	2.62059	0.01070^a
CXCR4 expression in the LN cortex	-0.060831	-0.51712	0.606655
CXCR4 expression in the LN medulla	0.467999	4.49357	0.00003^a
Perineural invasion
CXCR4 expression in the LN sinuses	0.082836	0.70531	0.48289
CXCR4 expression in the LN follicles	-0.187479	-1.61953	0.10971
CXCR4 expression in the LN cortex	-0.195884	-1.69497	0.09440
CXCR4 expression in the LN medulla	0.095575	0.81471	0.41792
Intraductal component
CXCR4 expression in the LN sinuses	0.003855	0.03271	0.97400
CXCR4 expression in the LN follicles	-0.242443	-2.12046	0.03741
CXCR4 expression in the LN cortex	-0.226872	-1.97661	0.05192
CXCR4 expression in the LN medulla	0.115281	0.98475	0.32804
Breast cancer subtype
CXCR4 expression in the LN sinuses	0.189883	1.64107	0.10515
CXCR4 expression in the LN follicles	-0.010422	-0.08844	0.92978
CXCR4 expression in the LN cortex	0.360217	3.27649	0.00162^a
CXCR4 expression in the LN medulla	0.028502	0.24195	0.80951
Estrogen receptor status
CXCR4 expression in the LN sinuses	-0.027475	-0.23322	0.81625
CXCR4 expression in the LN follicles	-0.087522	-0.74551	0.45839
CXCR4 expression in the LN cortex	0.050522	0.42924	0.66903
CXCR4 expression in the LN medulla	0.170558	1.46875	0.14626
Progesterone receptor status
CXCR4 expression in the LN sinuses	0.144467	1.23884	0.21943
CXCR4 expression in the LN follicles	0.303606	2.70380	0.00855^a
CXCR4 expression in the LN cortex	0.171745	1.47929	0.14343
CXCR4 expression in the LN medulla	0.399572	3.69856	0.00042^a
Human epidermal growth factor receptor 2 status
CXCR4 expression in the LN sinuses	0.158267	1.36008	0.17805
CXCR4 expression in the LN follicles	0.260292	2.28750	0.02511^a
CXCR4 expression in the LN cortex	0.122659	1.04871	0.29782
CXCR4 expression in the LN medulla	0.249569	2.18686	0.03200^a
Ki67 index
CXCR4 expression in the LN sinuses	0.186882	1.61418	0.11086
CXCR4 expression in the LN follicles	0.084581	0.72027	0.47369
CXCR4 expression in the LN cortex	0.397658	3.67751	0.00045^a
CXCR4 expression in the LN medulla	0.159837	1.37392	0.17373

^aP value < 0.0250 is considered significant.

t(N-2): The value of the Student’s t-test for the number of degrees of freedom n-2. CXCR4: C-X-C motif chemokine receptor 4; LN: Lymph node.

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Citation: Senchukova MA, Ishemgulov AT, Letuta SN, Saidler NV, Tagabilev DG. Changes in the metabolism of axillary lymph node cells as a predictor of regional metastasis in breast cancer. World J Exp Med 2026; 16(3): 125128
URL: https://www.wjgnet.com/2220-315X/full/v16/i3/125128.htm
DOI: https://dx.doi.org/10.5493/wjem.125128

Senchukova MA, Ishemgulov AT, Letuta SN, Saidler NV, Tagabilev DG. Changes in the metabolism of axillary lymph node cells as a predictor of regional metastasis in breast cancer. World J Exp Med 2026; 16(3): 125128 [DOI: 10.5493/wjem.125128]

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