Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns

Table 6 Diagnostic performance of microRNAs and other tumor biomarkers for differentiating between breast cancer patients (grade II vs grade III)

Parameters	Area under the curve	Cut-off value	Sensitivity (%)	Specificity (%)	P value	95%CI
MiR-21	0.997	3.79	95.83	100.00	0.001	0.921-1.000
MiR-221	0.843	2.11	75.00	96.00	0.001	0.711-0.931
MiR-1246	1.000	4.26	100.00	100.00	0.001	0.927-1.000
MiR-145	0.941	0.26	91.67	88.00	0.001	0.834-0.988
MiR-382	0.952	0.24	87.50	92.00	0.001	0.849-0.992
8-hydroxy-2′-deoxyguanosine	0.627	3232	79.17	56.00	0.125	0.477-0.761
Cancer antigen 15-3	0.768	235.3	87.50	68.00	0.001	0.626-0.877

MiRNAs: MicroRNAs.