Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns

Table 4 Diagnostic performance of microRNAs and other tumor biomarkers in breast cancer patients (grade II) relative to the control group

Parameters	Area under the curve	Cut-off value	Sensitivity (%)	Specificity (%)	P value	95%CI
MiR-21	0.988	1.25	100.0	95.0	0.000	0.962-1.000
MiR-221	0.804	1.06	88.0	75.0	0.001	0.664-0.944
MiR-1246	0.974	1.99	92.0	95.0	0.000	0.935-1.000
MiR-145	0.950	0.46	84.0	95.0	0.000	0.893-1.000
MiR-382	0.888	0.77	96.0	75.0	0.000	0.780-0.996
8-OHdG	0.996	1822.00	100.0	95.0	0.000	0.985-1.000
Cancer antigen 15-3	0.982	158.15	88.0	100.0	0.000	0.953-1.000
MiR-145 + MiR-382 + MiR-1246	1.000	-	100.0	100.0	0.000	1.000-1.000
MiR-145 + 8-OHdG	1.000	-	100.0	100.0	0.000	1.000-1.000

MiRNAs: MicroRNAs; 8-OhdG: 8-hydroxy-2′-deoxyguanosine.