Circulating microRNAs and serum proteins in breast cancer patients: Diagnostic relevance and grade-specific expression patterns

Table 1 The clinicopathological features of breast cancer patients, n (%)

Parameters		Groups		χ²	P value
		Grade II	Grade III
Estrogen receptor	Positive	20 (80.00)	14 (58.30)	2.706	0.100
	Negative	5 (20.00)	10 (41.70)
Progesterone receptor	Positive	22 (88.00)	13 (54.20)	6.868	0.009
	Negative	3 (12.00)	11 (45.80)
Human epidermal growth factor receptor 2	Positive	19 (76.00)	10 (41.70)	5.975	0.015
	Negative	6 (24.00)	14 (58.30)
Family history	Positive	12 (48.00)	7 (29.20)	1.829	0.176
	Negative	13 (52.00)	17 (70.80)
Tumor size	1	9 (36.00)	2 (8.30)	10.599	0.014
	2	13 (52.00)	10 (41.70)
	3	0 (0.00)	2 (8.30)
	4	3 (12.00)	10 (41.70)
Lymph nodal involvement	0	18 (72.00)	8 (33.30)	7.772	0.050
	1	5 (20.00)	9 (37.50)
	2	1 (4.00)	4 (16.70)
	3	1 (4.00)	3 (12.50)
Metastasis	0	22 (88.00)	18 (75.00)	1.380	0.240
	1	3 (12.00)	6 (25.00)
Metastatic	Yes	3 (12.00)	6 (25.00)	1.380	0.240
	No	22 (88.00)	18 (75.00)
Pathological subtype	Invasive ductal carcinoma	21 (84.00)	24 (100.00)	4.181	0.124
	Invasive lobular carcinoma	2 (8.00)	0 (0.00)
	Other	2 (8.00)	0 (0.00)