Flavonoids extract from Vitex negundo inhibit autophagy by targeting PI3K/AKT/mTOR/p70S6K/ULK signaling cascade in cancerous cells

doi:10.5493/wjem.v15.i3.104678

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World Journal of Experimental Medicine

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Exp Med. Sep 20, 2025; 15(3): 104678
Published online Sep 20, 2025. doi: 10.5493/wjem.v15.i3.104678

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Figure 4 Biochemical mechanism of phosphoinositide 3-kinase, phosphatase and tensin homolog deleted on chromosome 10 and protein kinase B regulation. PI3K: Phosphoinositide 3-kinase; mTOR: Mammalian target of rapamycin; PIP2: Phosphorylinositol 4,5-bisphosphate; PIP3: Phosphatidylinositol 3,4,5-trisphosphate; AKT: Protein kinase B; PTEN: Phosphatase and tensin homolog deleted on chromosome 10. Created in BioRender.com.

Citation: Garg G, Chaudhary S, Khatana K, Bharadwaj A. Flavonoids extract from Vitex negundo inhibit autophagy by targeting PI3K/AKT/mTOR/p70S6K/ULK signaling cascade in cancerous cells. World J Exp Med 2025; 15(3): 104678
URL: https://www.wjgnet.com/2220-315X/full/v15/i3/104678.htm
DOI: https://dx.doi.org/10.5493/wjem.v15.i3.104678