Flavonoids extract from Vitex negundo inhibit autophagy by targeting PI3K/AKT/mTOR/p70S6K/ULK signaling cascade in cancerous cells

Figure 2 Schematic representation of the phosphoinositide 3-kinase/ mammalian target of rapamycin/ribosomal protein S6 kinase pathway illustrates that ribosomal protein S6 kinase is located downstream of phosphoinositide 3-kinase and mammalian target of rapamycin. p70S6K: Ribosomal protein S6 kinase; PI3K: Phosphoinositide 3-kinase; mTOR: Mammalian target of rapamycin; PIP2: Phosphorylinositol 4,5-bisphosphate; PIP3: Phosphatidylinositol 3,4,5-trisphosphate.