Keratoconus therapeutics advances

Table 2 Paraclinic criteria for diagnosis of keratoconus[4]

Criteria	Values in keratoconus
Curvature	> 46 to 47 D
Asymetry I-S	> 1.4 D
Irregularity	> 20 or 30 degrees with respect to the vertical meridian
Keratometric difference between the 2 eyes	> 1 D
Anterior elevation	< 15 m in Placido rings images and < 12 m in Scheimpflug images
Posterior elevation	< 35 m in Placido rings images and < 18 m in Scheimpflug images
Pachymetry	Thinnest, decentered point, difference of 100 m between center and periphery
Aphericity (Q)	Between -0.5 and < -1
Eccentricity	Approaching 1
Form factor	Approaching 0
Corneal irregularity	> 1.1-5
Medium toric keratometry	47.3-60 D
Surface irregularity index	> 1.55
Predicted corneal acuity (Holladay Report)	> 0
Keratoconus index (Maeda)	> 0
Keratoconus % index	> 100
Keratoconus prediction index	> 0.38
Surface variation index	> 41
Vertical asymmetry index	0.32
Keratoconus index	> 1.07
Central keratoconus index	> 1.03
Smallest curvature radius	> 6.71
Largest asymmetry index	> 21
Height decentration index	> 0.016
Aberration coefficient	> 1
Aberration	Vertical Coma and Coma-like RMS (> 1.5 m)
Corneal volume analysis	> 57.98 ± 2.65 mm3
Corneal hysterisis	> 9.64 mmHg
Corneal resistance factor	> 9.6 mmHg