Targeting remyelination treatment for multiple sclerosis

Table 2 Drug classes identified in remyelination screens

Drug class	Compounds	Ref.
Adrenergic agonist	Methoxamine, nerepinephrine, tolaxoline, salmeterol	[55]
Dopamine antagonists	Opipramol, flupentixol, fluphenazine, trifluoperazine, perphenazine, quetiapine	[55,57]
Dopamine uptake inhibitor/dopamine agents	Vanoxerine, GBR12935, methyldopa	[55]
Histamine antagonists	Clemastine, doxylamine, clemizole	[55,57]
Adrenergic antagonist	Opipramol, trifluoperazine, Cgp-26505, tolazoline, quetiapine	[55,57]
Anticholinergics/cholinesterase reactivators	Homatropine, clemastine, benztropine, disopyramide, trospium, diacetyl-monoxime, tiotropium, oxybutynin, atropine, ipratropium, hyosamine, atropine, methy atropine, octatropine, glycpyrrolate, carbetapentane, piperildolate, bevonium, propiverine, dicyclomine, mepenzolate, trihexylphenidyl	[55,57]
Phosphodiesterase inhibitor	8-bromo cyclic GMP, IBMX, enprofylline, enoximone, rolipram	[55]
PPAR agonist	GW-1929	[55]
Ion channel blockers	Gabapentin, 8-aminobenzoic acid, disopyramide, oubain	[55]
Serotonin modulators	Brl-15572, paroxetine, clemizole, quetiapine	[55,57]
Glutamate receptor antagonist	UPF-523, l-aminodan-1,5-dicarboxylic acid	[55]
Beta-catenin inhibitor	XAV939	[55]
Retinoic acid receptor agonist	Retinoids, AM580	[55,94]
Thyroid hormone receptor agonist	T3	[55,57]
COX-2 inhibitors	Niflumic acid, flunixin	[55]
HMG-CoA reductase Inhibitor	Mevastatin, simvastatin	[55]
Rho kinase inhibitor	Ml-7, Ml-9, fasudil	[55,63,94]
Antifungal/antibacterial	Ketoconazole	[55]
Cathartic/emetic	Emetine	[55]
Opioid antagonists	Levallorphan	[55]
Glucocorticoids	Dexamethasone, hydrocortisone, budesonide, flunisolide	[94]
EGF/ErbB2 inhibitor	PD174265	[94]

PPAR: Peroxisome proliferator activator receptor. COX-2: Cyclooxygenase-2; HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme A; EGF: Epidermal growth factor.