Variation in experimental autoimmune encephalomyelitis scores in a mouse model of multiple sclerosis

Table 3 Experimental autoimmune encephalomyelitis scores using the 0.5 point scale

	Tsunoda et al[26]	Storch et al[27]	Greter et al[28]	Kihara et al[29]
Strain	SJL/J mice	BN and DA rat	C57/BL mice	C57/BL mice
Antigen	PLP	MOG1-125	MOG35-55	MOG35-55
0	No clinical disease	ND	No detectable signs of EAE	No signs
0.5	Loss of tonicity of the distal half of the tail	Partial loss of tail tone	Distal limp tail	Mild loss of tail tone
1	Complete loss of tail tonicity	Complete tail atony	Complete limp tail	Complete loss of tail tone
1.5	ND	ND	Limp tail and distal limb weakness	Mildly impaired righting reflex
2	Mild hind leg paresis	Hind limb weakness	Unilateral partial limb paralysis	Abnormal gait and/or impaired righting reflex
2.5	ND	ND	Bilateral partial hind limb paralysis	Hind limb paresis
3	Moderate hind leg paralysis	Hind limb paralysis	Complete bilateral hind limb paralysis	Hind limbs paralysis
3.5	ND	ND	Complete bilateral hind limb paralysis and unilateral forelimb paralysis	Hind limb paralysis with hind body paresis
4	Complete paraplegia	Tetraplegy, moribund state	Total paralysis of fore and hind limbs	Hind and fore limb paralysis
4.5	ND	ND	ND	Moribund
5	quadriplegia, moribund state or death	Death	Death	Death
5.5	ND	ND	ND	ND
6	ND	ND	ND	ND

ND: Not defined.