P2X7 receptor in skin biology and diseases

Table 3 Roles of the P2X7 receptor in human skin diseases

Disease	Observations
Allergic contact dermatitis	Increased P2X7 expression in atopic dermatitis lesions[88]
Irritant contact dermatitis	ND
Psoriasis	Increased P2X7 expression in psoriatic skin lesions[30,88]
Cutaneous graft-vs-host disease	ND
Wound healing	P2X7 activation promotes VEGF release from monocytes[103]
Skin transplantation	ND
Melanoma	P2X7 is present on melanoma cells[117,118] and cell lines[119], with increased expression compared to normal melanocytes[119]
	P2X7 activation induces A375 melanoma[118] but suppresses HT168-M1 melanoma cell death[119]
Basal cell carcinoma	P2X7 is present in necrotic tumour centres and apoptotic tumour cells, and correlates inversely with tumour aggressiveness[123]
Squamous cell carcinoma	P2X7 is present in apoptotic tumour cells and its activation causes A431 SCC cell death[123]

ND: Not determined; SCC: Squamous cell carcinoma; VEGF: Vascular endothelial growth factor.