P2X7 receptor in skin biology and diseases

Table 2 Roles of the P2X7 receptor in mouse models of skin disease

Disease	Observations
Allergic contact dermatitis	P2X7 blockade or deficiency impairs CHS[89]
Irritant contact dermatitis	P2X7 blockade or deficiency impairs croton oil-induced oedema, IL-1β production and neutrophil infiltration[69]
Psoriasis	ND
Cutaneous graft-vs-host disease	P2X7 blockade or deficiency increases survival and reduces disease severity, serum concentrations of IFN-γ, TNF-α and IL-6 in allogeneic mouse models[98,99]
Wound healing	P2X7 deficient macrophages display reduced migration in an in vitro wound repair model[102]
Skin transplantation	P2X7 blockade or deficiency prevents allogeneic skin transplant rejection[109]
Melanoma	ATP injection impairs A375 melanoma cell growth in immuno-compromised mice[120] P2X7 blockade inhibits B16 melanoma cell growth in immuno-competent mice[121,122] P2X7 deficiency impairs B16 melanoma cell migration in vitro[102] P2X7 deficiency in host leads to increased B16 melanoma growth and metastasis[102]
Basal cell carcinoma	ND
Squamous cell carcinoma	P2X7 deficiency in host enhances chemical-induced carcinogenesis[18] BzATP injection led to tumour apoptosis[18]

ATP: Adenosine triphosphate; BzATP: 2',3’-O-(4-benzoyl) benzoyl ATP; CHS: Contact hypersensitivity; IFN: Interferon; IL: Interleukin; ND: Not determined; TNF: Tumour necrosis factor.