Review
Copyright ©The Author(s) 2016.
World J Dermatol. Feb 2, 2016; 5(1): 17-51
Published online Feb 2, 2016. doi: 10.5314/wjd.v5.i1.17
Table 2 Adverse effects of methotrexate therapy
System involvedAdverse effects
GeneralFatigue, headaches, chills and fever, dizziness
SkinPruritus, pain and burning, urticaria, mild reversible alopecia, ecchymosis, acute ulcerations of psoriatic lesions, reactivation of phototoxic responses
BloodBone marrow depression, leukopenia leading to decreased resistance to infection, anemia, thrombocytopenia, bleeding, and megaloblastic anemia, Pancytopenia
Gastrointestinal systemNausea and anorexia, diarrhea, vomiting, ulcerative stomatitis, pharyngitis, enteritis
Urinary systemAzotemia, microscopic hematuria, cystitis, nephropathy
Respiratory systemAcute pneumonitis, pulmonary fibrosis
Nervous systemHeadaches, dizziness, drowsiness, blurred vision, acute depression
Reproductive systemTeratogenesis, defective oogenesis, menstrual dysfunction, reversible oligospermia, defective spermatogenesis
Uncommon side effectsAnaphylaxis, acral erythema, epidermal necrosis, vasculitis, osteopathy, lymphoma