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Copyright ©The Author(s) 2015.
World J Dermatol. May 2, 2015; 4(2): 108-113
Published online May 2, 2015. doi: 10.5314/wjd.v4.i2.108
Table 2 Evidence of the clinical studies on the effectiveness of moisturizers containing anti-inflammatory agents
Ref.Active ingredientsDesign + Population + AgeOutcome measurementResults
Udompataikul et al[6]Licochalcone A, LARandomized controlled-investigator blind; n = 28, mean age = 5.8 yr old (2-15 yr old)SCORAD scoreResponse rate 73.33% The effective- ness of LA was equal to 1% HC
Wananukul et al[7]Licochalcone A, LARandomized, double-blind, split-side, study n = 55, age 3 mo-14 yr oldSCORAD score, TEWLThe effectiveness of LA was equal to 1% HC
Angelova Fischer et al[8]LALDMRandomized controlled-investigator blind, study; n = 20 mean age = 26.2 yr oldSCORAD score, TEWL, skin -conductance, Staphylococcus aureus colonizationLALDM was equal to 1% HC, and LALDM can reduce Staphylococcus aureus colonization
Abramovits et al[10]Glycyrrhetinic acid, shea butter (MASO63DP)Randomized, vehicle-controlled study; n = 218, age 18-84 years oldEASI score, IGAThe effectiveness of MASO63DP was more effective than vehicle
Boguniewicz et al[11]Glycyrrhetinic acid, shea butter (MASO63DP)Randomized, vehicle-controlled study; n = 142, age 18-84 yr oldEASI score, IGAThe effectiveness of MASO63DP was more effective than vehicle
Udompataikul et al[20]Dexpanthenol, petrolatumOpen label; n = 30 mean age 7.19 yr oldSCORAD scoreThe effectiveness of dexpanthenol ointment was equal to 1% HC
Eberlein et al[30]PEA, phytosterol ceramide in dermal membrane structureMulticenter study (moisturizers as adjuvant treatment) n = 2456 (adult 1533, children 923)Clinical and pruritic VASPruritus reduction (VAS), Improvement of sleep quality, Reduction of previous use of topical corticosteroid were significant difference
Udompataikul et al[20]Linoleic acids from Spent grain wax, shea butter, argan oil; phytosterols (LP)Randomized investigator blind; n = 31, age = 4.24 yr oldSCORAD scoreThe effectiveness of LP was equal to 1% HC
Lee et al[40]Multilamellar emulsion – pseudoceramide, type III synthetic ceramide (PC)An open crossover studyClinicalPC cream was more effective than urea cream