Case Control Study
Copyright ©The Author(s) 2018.
World J Clin Oncol. Nov 10, 2018; 9(7): 133-139
Published online Nov 10, 2018. doi: 10.5306/wjco.v9.i7.133
Table 1 Clinical-pathological characteristic of 216 patients with rectal carcinoma with preoperative chemo-radiotherapy, divided by type of pathological response n (%)
No pathological complete response group (controls) (n = 144)Pathological complete response group (cases) (n = 72)P
Median age (yr ± SD)56.67 ± 11.9457.22 ± 13.650.7593
Sex
Female48 (33.3)24 (33.3)1.01
Male96 (66.7)48 (66.7)
Histologic grade
G130 (20.8)27 (37.5)
G244 (30.6)6 (8.3)< 0.0011
G370 (48.6)39 (54.2)0.1471
Budding
Low (0-4 buds)63 (43.8)44 (61.6)0.0161
High (5 or more buds)81 (56.2)28 (38.4)
Missmatch repair status
MMR proficient112 (77.8)41 (56.9)0.0011
MMR defective32 (22.2)31 (43.1)
CDX2 expression
Absent8 (5.6)7 (9.7)0.1951
Present136 (94.4)65 (90.3)
MLH1
Non expressed23 (16)26 (36.1)0.0011
Normal121 (84)46 (63.9)
PMS2
Non expressed23 (16)26 (36.1)0.0011
Normal121 (84)46 (63.6)
MSH2
Non expressed11 (7.6)00.0102
Normal133 (92.4)72 (100)
MSH6
Non expressed12 (8.3)4 (5.6)0.5872
Normal132 (91.7)68 (94.4)
Lymphovascular invasion
Absent130 (90.3)63 (87.5)0.1051
Present14 (9.7)9 (12.5)

  • Citation: Lino-Silva LS, Gamboa-Domínguez A, Zúñiga-Tamayo D, Salcedo-Hernández RA, Cetina L, Cantú-de-León D. Mismatch repair protein expression and intratumoral budding in rectal cancer are associated with an increased pathological complete response to preoperative chemoradiotherapy: A case-control study. World J Clin Oncol 2018; 9(7): 133-139
  • URL: https://www.wjgnet.com/2218-4333/full/v9/i7/133.htm
  • DOI: https://dx.doi.org/10.5306/wjco.v9.i7.133