Characteristics of Clostridium difficile infection in patients hospitalized with myelodysplastic syndrome or acute myelogenous leukemia

Table 1 Characteristics of Patients with C. difficile infection n (%)

Variable (per patient)	CDI (n = 34)
Diagnosis
AML	31 (91)
MDS	3 (9)
Gender
Male	15 (44.1)
Female	19 (55.9)
PPI therapy1	22 (64.7)
Prior history of CDI	5 (14.8)
Receipt of chemotherapy2	31 (91)
Type of chemotherapy
Cytarabine-based chemotherapy	21 (61.7)
DNA hypomethylating agent-based chemotherapy	11 (32.3)
Death/referral to hospice	8 (23.5)
Severity of CDI3
Mild-moderate	29 (85.2)
Severe	4 (11.7)
Severe-complicated	1 (2.9)
Total number of CDI episodes during hospitalization
1	31 (91)
2	3 (9)
Recurrence of CDI	4 (11.7)
ICU admission	8 (23.5)
Bowel perforation	0
Need for surgical intervention	1 (3)

¹PPI therapy defined as use of PPI documented at the time of hospital admission;

²Receipt of chemotherapy defined as being given within 30 d of hospital admission;

³Severity as defined by the SHEA/IDSA Guidelines[12]. CDI: Clostridium difficile infection; AML: Acute myeloid leukemia; MDS: Myelodysplastic syndrome; PPI: Proton-pump inhibitor; ICU: Intensive care unit.