Circulating cytokeratin-positive cells and tumor budding in colorectal cancer

Table 2 Literature: Circulating tumor cells in the mesenteric blood

Ref.	n	Year	Method	Material	Stages	%positive	Prognostic relevance
Leather et al[18]	42	1993	ICC	Mesenteric and peripheral blood	I, II, III, IV	15	n.a.
Nakamori et al[19]	35	1997	PCR	Mesenteric and peripheral blood	I, II, III, IV	26	uv predictive for recurrence
Luo et al[20]	54	1999	PCR	Mesenteric blood	I, II, III, IV	76	Predictive for metastases
Taniguchi et al[22]	53	2000	PCR	Mesenteric and peripheral blood	I, II, III	68	uv survival
Yamaguchi et al[23]	52	2000	PCR	Mesenteric blood	I, II, III, IV	44	mv survival
Iinuma et al[21]	23	2000	MACS	Mesenteric blood	I, II, III, IV	39	uv survival
Fujita et al[25]	35	2001	PCR	Mesenteric blood	I, II, III	29	uv recurrence/survival
Etoh et al[24]	24	2001	PCR	Mesenteric blood	I, II, III, IV	29	uv recurrence/survival
Guller et al[26]	39	2002	PCR	Mesenteric and peripheral blood	I, II, III	81/282	3
Tien et al[27]	58	2002	PCR	Mesenteric and peripheral blood	II, III, IV	454	n.a.
Akashi et al[28]	80	2003	PCR	Mesenteric blood	I, II, III	44	uv metastatic disease; mv no
Nozawa et al[29]	41	2003	RTA	Mesenteric and peripheral blood	I, II, III, IV	37	uv predictive for metastatic disease
Sunouchi et al[30]	37	2003	PCR	Mesenteric blood	I, II, III, IV	43	uv survival
Zhang et al[32]	58	2005	PCR	Bone marrow, portal blood, peripheral blood	I, II, III, IV	74	correlation with stage - no outcome analysis
Sadahiro et al[31]	100	2005	PCR	Mesenteric and peripheral blood	I, II, III	455/486	no
Kanellos et al[34]	108	2006	PCR	Mesenteric blood	I, II, III	11	uv metastatic disease/survival
Iinuma et al[33]	167	2006	PCR	Mesenteric and peripheral blood	I, II, III, IV	10/347	mv survival
Tseng et al[35]	135	2015	FACS	Mesenteric	I, II, III	68	mv survival

¹Blood;

²Blood and peritoneal fluid;

³No separate evaluation for blood samples;

⁴Multiple measurements;

⁵Mesenteric blood;

⁶Peripheral blood;

⁷Mesenteric. n.a.: Not available; uv: Uni-variable; mv: Multi-variable; ICC: Immunocytochemistry; PCR: Polymerase chain reaction; MACS: Magnetic activated cell sorting; FACS: Fluorescence activated cell sorting.