Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants

Figure 2 Mutant epidermal growth factor receptor vs wt-epidermal growth factor receptor signaling. While wtEGFR signaling to Akt and Erk is subjected to Cbl-mediated degradation, mutant EGFR cooperates with Src to exaggerate signaling through downstream effectors. EGFR: Epidermal growth factor receptor.