Clinical application of DNA ploidy to cervical cancer screening: A review

doi:10.5306/wjco.v5.i5.931

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Dec 10, 2014 (publication date) through Jun 4, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Dec 10, 2014; 5(5): 931-965
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.931

Table 16 Test performance indicators for DNA Cytometry, hrHPV tests and combined DNA Cytometry and hrHPV tests, for Cytology ASCUS cases, Ref[169]

	875 Cases (157 CIN2+)	294 Cases (53 CIN2+)
Performance indicator for CIN2+ (%)	DNA Ploidy	hrHPV	DNA Ploidy	DNA Ploidy and hrHPV
bSensitivity	98.8	98.1	96.2	96.2
bSpecificity	47.5	32.0	56.0	73.4
bPPV	29.1	24.1	32.5	44.3
bNPV	99.4	98.7	98.5	98.9

hrHPV: High risk HPV; CIN2+: Cervical intraepithelial neoplasia, grade 2 or higher; PPV: Positive predictive value; NPV: Negative predictive value. Prefix “b”: From among biopsy cases only.

Citation: Garner D. Clinical application of DNA ploidy to cervical cancer screening: A review. World J Clin Oncol 2014; 5(5): 931-965
URL: https://www.wjgnet.com/2218-4333/full/v5/i5/931.htm
DOI: https://dx.doi.org/10.5306/wjco.v5.i5.931