Polymorphisms in base excision repair genes: Breast cancer risk and individual radiosensitivity

Table 2 List of meta-analyses on 8-oxoguanine DNA glycosylase 1, apurinic/apyrimidinic endonuclease 1 and poly (ADP-ribose) polymerase-1 single nucleotide polymorphism and risk of breast cancer

Ref.	BER gene	SNPs	Number of studies analysed	Result
Yuan et al[27]	OGG1	Ser326Cys	10	This SNP is significantly associated with a protective effect against BC in European subjects (additive and dominant model)
Ding et al[28]	OGG1	Ser326Cys	4	There was a lack of association between this SNP and BC risk in a European population
Gu et al[29]	OGG1	Ser326Cys	11	There was a lack of association between this SNP and BC risk
Wei et al[33]	OGG1	Ser326Cys	12	This SNP did not have a significant effect on BC
Wu et al[35]	PARP-1 (ADPRT)	Val762Ala	6	There was no association between this SNP and BC (all genetic models)
Wu et al[35]	APE1	Asp148Glu	5	There was no association between this SNP and BC (all genetic models)

OGG1: 8-oxoguanine DNA glycosylase 1; APE1: Apurinic/apyrimidinic endonuclease 1; PARP-1: Poly (ADP-ribose) polymerase-1; SNP: Single nucleotide polymorphism; BC: Breast cancer; BER: Base excision repair; Ser: Serine; Cys: Cysteine; Val: Valine; Ala: Alanine; Asp: Aspartic acid; Glu: Glutamic acid; ADPRT: ADP ribosyl transferase.