Erlotinib usage after prior treatment with gefitinib in advanced non-small cell lung cancer: A clinical perspective and review of published literature

Table 1 Baseline characteristics of subjects in studies evaluating response to erlotinib after gefitinib

Ref.	Year	Country	Type of study	No. of patients	Gender (M/F)	Smoking status (smokers/NS)	Histology (A/S/other)
Garfield[9]	2005	United States	Case report	1	1/0	1/0	0/0/1
Viswanathan et al[16]	2005	United States	Case report	5	1/4	2/3	NA
Walther et al[17]	2006	United Kingdom	Case report	1	0/1	0/1	1/0/0
Chang et al[18]	2007	Taiwan	Case report	1	1/0	1/0	1/0/0
Cho et al[19]	2007	South Korea	Prospective	21	10/11	10/11	16/3/2
Gridelli et al[32]	2007	Italy	Case report	3	0/3	0/3	3/0/0
Kim et al[33]	2007	South Korea	Case report	1	0/1	0/1	1/0/0
Costa et al[23]	2008	United States	Retrospective	18	7/11	7/11	16/0/2
Lee et al[21]	2008	South Korea	Prospective	23	4/19	0/23	22/0/1
Vasile et al[22]	2008	Italy	Prospective	8	4/4	1/7	6/0/2
Wong et al[20]	2008	Singapore	Retrospective	14	4/10	1/13	10/1/3
Wong et al[34]	2008	Singapore	Case report	1	0/1	0/1	1/0/0
Wu et al[35]	2008	Taiwan	Case report	1	0/1	0/1	1/0/0
Katayama et al[36]	2009	Japan	Retrospective	7	2/5	NA	7/0/0
Sim et al[24]	2009	South Korea	Retrospective	16	0/16	0/16	16/0/0
Zhou et al[25]	2009	China	Prospective	21	14/7	10/11	8/9/4
Wong et al[26]	2010	China	Retrospective	21	2/19	1/20	19/0/2
Asami et al[27]	2011	Japan	Retrospective	42	13/29	14/28	42/0/0
Hata et al[29]	2011	Japan	Retrospective	125	49/76	55/70	117/NA/8
Masuda et al[37]	2011	Japan	Case report	3	3/0	NA	3/0/0
Shoji et al[38]	2011	Japan	Case report	1	1/0	NA	1/0/0
Song et al[39]	2011	China	Retrospective	20	9/11	5/15	18/0/2
Takenaka et al[40]	2011	Japan	Case report	1	0/1	0/1	1/0/0
Saito et al[41]	2012	Japan	Retrospective	21	9/12	9/12	19/0/2
Tetsumoto et al[42]	2012	Japan	Case report	2	0/2	0/2	2/0/0
Koyama et al[43]	2013	Japan	Retrospective	1041	56/48	50/54	90/6/8

¹Of the 104 patients, only 54 had prior treatment with gefitinib. A: Adenocarcinoma; S: Squamous cell carcinoma; M: Male; F: Female; NA: Not available; smokers: Includes current and ex smokers; NS: Non-smokers.