Genomic era diagnosis and management of hereditary and sporadic colon cancer

doi:10.5306/wjco.v5.i5.1036

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 5, Issue 5

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (7461)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-1) series.

Item

Count

PDF

562

WORD

354

HTML

4409

Figures (1-1)

111

Tables (1-1)

135

Sum=5571

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1210

Download

680

Sum=1890

Dec 10, 2014 (publication date) through Apr 22, 2024

Times Cited of This Article

Times Cited (8)

Journal Information of This Article

Publication Name

World Journal of Clinical Oncology

ISSN

2218-4333

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Minireviews

World J Clin Oncol. Dec 10, 2014; 5(5): 1036-1047
Published online Dec 10, 2014. doi: 10.5306/wjco.v5.i5.1036

Table 1 Evolving genomic tools for management of colon cancer

	Detection	Diagnosis	Management
Clinically available	Fecal occult blood test	Single gene sequencing (APC) Multigene panel next generation sequencing	Targeted gene analysis for therapeutic contraindications (KRAS, UGT1A1)
Research basis	Fecal genomic DNA analysis	Tumor genome sequencing for prognosis
Future application	Cell free genomic DNA sequencing		Development of gene pathway directed therapeutics (e.g., small molecule inhibitors)

APC: Adenomatous polyposis coli; KRAS: Kirsten rat sarcoma viral oncogene homolog; UGT1A1: Uridine diphosphate-glucuronosyl transferase 1A1.

Citation: Esplin ED, Snyder MP. Genomic era diagnosis and management of hereditary and sporadic colon cancer. World J Clin Oncol 2014; 5(5): 1036-1047
URL: https://www.wjgnet.com/2218-4333/full/v5/i5/1036.htm
DOI: https://dx.doi.org/10.5306/wjco.v5.i5.1036