Estrogen receptors as the novel therapeutic biomarker in non-small cell lung cancer

Table 3 Previous studies of estrogen receptors as prognostic markers in non-small cell lung cancer

Ref.	ER subtype	Methods	Location	Prognosis
Kawai et al[9]	α	IHC	Cytoplasm	Worse
	β	IHC	Nucleus	Better
Wu et al[11]	β	IHC	Nucleus	Better
Schwartz et al[10]	β	IHC	Nucleus	Better (male)
Skov et al[14]	β	IHC	Nucleus	Better (male)
Nose et al[16]	α	IHC	Cytoplasm	Worse
Abe et al[18]	β	IHC	Nucleus	Better
Mauro et al[20]	β	IHC	Nucleus	Better
Olivo-Marston et al[30]	α	RT-PCR	NS	Worse
Stabile et al[21]	β	IHC	Cytoplasm	Worse
Rouquette et al[25]	α	IHC	Nucleus	Better
Rades et al[23]	α	IHC	NS	Worse
Karlsson et al[28]	β	IHC	Nucleus	Better (ADCA)
Liu et al[29]	β2,5	IHC	Cytoplasm	Better

ER: Estrogen receptors; NS: Indicates not specified; ADCA: Adenocarcinoma; IHC: Immunohistochemistry; RT-PCR: Reverse transcription polymerase chain reaction.