MicroRNAs as lung cancer biomarkers

Table 1 MiRNAs from resected samples as biomarkers for the diagnosis of lung cancer

MiRNA	Scope	Sample	Ref.
mir-21, mir-191, mir-210, mir-155, mir-205, mir-24-2, mir-212, mir-214, mir-17-3p, mir-106a, mir-197, mir-192, mir-146, mir-203, mir-150, (UP) mir-126-5p, mir-143, mir-192-prec, mir-224, mir-126, mir-30a-5p, mir-140, mir-9, mir-124a-1, mir-218-2, mir-95, mir-145, mir-198, mir-216-prec, mir-219-1, mir-125a-prec, mir-26a-1-prec, mir-199b-prec, let-7a-2-prec, mir-27b, mir-32, mir-29b-2, mir-220, mir-33, mir-181c-prec, mir-101-1, mir-124a-3, mir-125a (DOWN)	Lung cancer vs normal	Solid (Not specified)	[28]
mir-21, mir-191, mir-155, mir-210, mir-24-2 (UP) mir-126-5p, mir-126-3p, mir-219-1, mir-95, mir-192-prec, mir-220, mir-216-prec, mir-204-prec, mir-188, mir-198, mir-145, mir-224 (DOWN)	ADs vs normal	Solid (Not specified)	[28]
mir-205, mir-191, mir-210, mir-17-3p, mir-203, mir-155, mir-21, mir-214, mir-212, mir-197 (UP) mir-224, mir-126*, mir-140, mir-29b, mir-143, mir-30a-5p (DOWN)	SCC vs normal	Solid (Not specified)	[28]
miR-31 (UP) miR-107, miR-185, let-7a (DOWN)	Lung cancer tissue vs normal	Solid (Not specified)	[70]
miR-26a, let-7g, let-7f, miR-98, miR-29a, let-7c, miR-30b, let-7i, let-7b, miR-29b, miR-26b, let-7a, miR-146b-5p, miR-195, miR-29c, miR-30d, miR-20a, miR-17, miR-19b, miR-106a, miR-16, let-7d, miR-106b, miR-181a, miR-498, miR-103, miR-107, miR-191, mir-663, miR-491-5p, let-7e, mir-654-5p (UP) miR-453, miR-509-3p (DOWN)	AD vs SCC; male smokers patients	Solid, formalin-fixed, paraffin-embedded	[71]
miR-17-5p, miR-20a, miR-20b, miR-93, miR-106a, miR-106b, miR-182, miR-183, miR-200a, miR-200c, miR-203, miR-210, miR-224 (UP) miR-125a, let7e (DOWN)	SCC vs normal	Solid, Snap-frozen	[72]
miR-30a, miR-140-3p, miR-182, miR-210, miR-486-5p	Stage I-III vs normal	Solid, Snap-frozen	[73]
miR-182, miR-200c, miR-141, miR-375, miR-7, miR-429, miR-200a, miR-370, miR-200b, miR-382 (UP) miR-126, miR-451, miR-195, miR-486-5p, miR-214, miR-199a-5p (DOWN)	Primary lung tumors vs metastases	Solid, formalin-fixed, paraffin-embedded	[74]
miR-205, miR-21 (relative expression)	AD vs SCC	Solid, formalin-fixed, paraffin-embedded	[75]
miR-21, miR-155 (UP)	LCNECs and SCLCs vs TCs and ACs	Solid, formalin-fixed, paraffin-embedded	[79]
miR-205, miR-27a, miR-29a, miR-29b, miR-34a (DOWN in NSCLC) miR-25, miR-375 (UP in NSCLC)	SCLC vs NSCLC	Solid, formalin-fixed, paraffin-embedded	[80]
miR-29a, miR-29b, miR-34a, miR-375 (DOWN in SQ) miR-205, miR-25, miR-27a (UP in SQ)	SCC vs AD	Solid, formalin-fixed, paraffin-embedded	[80]
miR-7, miR-21, miR-29b, miR-106a, miR-125a-5p, miR-129-3p, miR-205, miR-375 (relative expression)	Carcinoid, SCLC, and squamous and nonsquamous NSCLC	Solid, Fresh Biopsy	[81]
miR-21, miR-155, miR-7 (UP)	Tumor vs normal	Solid, fine-needle aspirate (FNA)	[82]
miR-21, miR-155 (UP)	NSCLC vs normal	Sputum	[96]
miR-205, miR-210, miR-708 (relative expression)	SCC vs normal	Sputum	[97]
miR-21, miR-200b, miR-375 and miR-486 (relative expression)	AD vs Normal	Sputum	[98]
miR-31, miR-210 (relative expression)	Stage I NSCLC vs normal	Sputum	[99]
miR-31, miR-210 (Relative Expression) + computed tomography	Stage I NSCLC vs normal	Sputum	[100]

AD: Adenocarcinoma; SCC: Squamous cell carcinoma; LCNEC: Large cell neuroendocrine carcinoma; SCLC: Small cell lung carcinoma; TC: Typical carcinoid; AC: Atypical carcinoid; NSCLC: Non-small cell lung cancer.