Resection of the primary tumor in stage IV breast cancer

Table 1 Ongoing randomized trials testing the worth of local therapy for an intact primary in women with stage IV breast cancer xvii

Country	Trial number	Accrual period	n	Initial therapy	Radiotherapy	Primary endpoint
India	NCT00193778	2005–12	350	Adriamycin-cytoxan	If indicated	Time to progression
Turkey	NCT00557986	2008–12	281	Surgery	For breast conservation	Survival
United States and Canada	NCT01242800	2011–16	368	Appropriate systemic therapy	Per standards for stageI-III	Survival
Netherlands	NCT01392586	2011–16	516	Surgery	For positive margins or palliation	2-yr survival
Austria	NCT01015625	2010–19	254	Surgery	Per standards for stageI-III	Survival
Japan	JCOG 1017	2011–16	410	Appropriate systemic therapy	No	Survival

JCOG: Japan Clinical Oncology Group; NCT number: A unique identification code given to each clinical study registered on ClinicalTrials.gov.