Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma

Table 3 Salvage treatment modalities and details for recurrent glioblastoma multiforme

Ref.	rGBM patients	Margin GK dose (range) Gy	Salvage resection	Salvage radiotherapy	Salvage chemotherapy
Skeie et al[9]	32	12.2 (8-20)	None	19 EBRT	3 Temo, 15 PCV
	19		All GTR	12 EBRT	1 Temo, 6 PCV
Park et al[10]	11	16 (13-18)	2 debulking	None	All BZ (9 w/irinotecan, 1 w/Temo)
	44	15 (10-20)	7 resection	1 EBRT	19 patients (no BZ)
Koga et al[28]	9	20	NR	NR	NR
	9	Extended field, 20	NR	NR	NR
Elliott et al[11]	16	15 (12-18)	14 GTR, 2 NTR	NR	NR
Pouratian et al[25]	26	6.0 (3.0-15.0)	NR	NR	NR
Kida et al[21]	54	14.7 (8-25)	NR	NR	NR
1Kong et al[23]	65	16 (12-50)	NR	NR	13 Temo or PCV
Kohshi et al[22]	11	22 (18-27) in 8 fractions followed by HBO therapy	2 patients	NR	NR
Hsieh et al[24]	26	12	NR	NR	NR

¹Kong et al[23] (2008) includes data from 0-5 cases treated with LINAC. rGBM: Recurrent glioblastoma multiforme; GK: Gamma Knife; HBO: Hyperbaric oxygen; GTR: Gross total resection; NTR: Near-total resection; EBRT: External beam radiation therapy; Temo: Temozolomide; PCV: Procarbazine, lomustine, and vincristine; BZ: Bevacizumab; NR: Data not reported or not segregated for rGBM patients.