A complete compilation of matrix metalloproteinase expression in human malignant gliomas

Figure 1 Structural groups of matrix metalloproteinases and their domain composition. Pre: Amino-terminal signal sequence, directing matrix metalloproteinases (MMPs) to the endoplasmic reticulum; SA: Signal anchor for cell membrane targeting; Fu: Recognition motif for intracellular furin-like serine proteinases, allowing intracellular activation of MMPs by cutting off the pro-domain at the cleavage site; Vn: Vitronectin-like insert; Fi: Collagen-binding type II repeats of fibronectin, HL: hinge linker, connecting the catalytic domain with the hemopexin domain, which mediates interaction with tissue inhibitors of metalloproteinases (TIMPs), cell-surface molecules and proteolytic substrates; CA: Cysteine array; TM: Single-span transmembrane domain; Cy: Cytoplasmic domain.