Analysis of the Hox epigenetic code

Table 2 Known roles of Ras-superfamily GTPases in Caenorhabditis elegans: Homologs in humans

C.elegansgene name	Human homolog	Developmental role(s)
Ras/Rap/Ral family
let-60	K-Ras	Cell fate determination, oocyte meiotic maturation, sex myoblast migration, axon pathfinding, olfaction, response to microbacterium nematophilum infection
Rho family
rho-1	RhoA	Cytokinesis, hypodermal contraction, P cell migration, axon pathfinding
cdc-42	Cdc42	Cytokinesis, embryonic polarity, axon pathfinding
ced-10	Rac1	Gastrulation, cell migration (P cells, distal tip cells), cell corpse phagocytosis, neuronal migration, axon pathfinding, vulval morphogenesis
rac-2	Rac1	Neuronal migration, axon pathfinding
mig-2	Mtl	Cell migration (P-cells, distal tip cells, Q cells and descendants), neuronal migration, axon pathfinding, vulval morphogenesis
Rab family
rab-1	Rab1	Innate immunity gene expression
rab-3	Rab3	Synaptic vesicle trafficking and release
Arf/Sar family
arl-6	Arf6	Ciliary vesicle trafficking and Bardet-Beidl syndromes
evl-20	Arf2	Microtubule organization, vulval cell division, tissue morphogenesis
Ran family
ran-1	Ran	Nuclear trafficking, nuclear reassembly, Kinetechore association with the mitotic spindle