Serendipity in anticancer drug discovery

Table 5 List of drugs found to be beneficial for conditions other than for which they were developed (clinical), the number of identified derivatives and their therapeutic notation

Clinical drugs	Ref.	Derivatives	Notation
Aminoglutethimide	[3,4]	0	Cancer
Alprostadil	[3]	4	Cardiovascular
Amphetamine	[1,3,4]	10	CNS
Aspirin	[1-3]	0	Cardiovascular/Cancer
Auranofin	[2,3]	0	Antirheumatic
Carbamazepine	[3]	1	CNS
Celecoxib	[2]	0	Cancer
Chlordiazepoxide	[1-4]	20	CNS
Chlorothiazide	[1,3,4]	11	Diuretic
Clofibrate	[3]	1	Cardiovascular
Dactinomycin	[3]	0	Cancer
Diisopropylfluorophosphate	[3]	0	Ocular
Diltiazem	[3]	0	Cardiovascular
Dimenhydrinate	[2-4]	0	CNS
Diphenhydramine	[3]	2	CNS
Diphenoxylate	[3,4]	1	Antidiarrheal
Dipyridamole	[3]	0	Cardiovascular
Disulfiram	[1,2,4]	0	Alcoholism treatment
Doxorubicin	[3]	5	Cancer
Etomidate	[3,4]	0	CNS
Finasteride	[2]	1	Baldness
Guanethidine	[3,4]	2	Cardiovascular
Haloperidol	[1,3,4]	1	CNS
Imatinib	[1]	0	Cancer
Imipramine	[1-4]	10	CNS
Iproniazid	[1-4]	1	CNS
Linezolid	[1]	0	Antibiotic
LSD	[1-4]	5	CNS
Meprobamate	[2,4]	1	CNS
Mercaptopurine	[1,3]	2	Immunosuppressive
Metronidazole	[3]	1	Antiprotozoal
Mifepristone	[3,4]	0	Hormonal
Minoxidil	[2]	0	Cardiovascular
Mycophenolic acid	[3]	1	Immunosuppressive
Naloxone	[3]	1	CNS
Norethindrone	[1,3,4]	11	Hormonal
Pethidine	[3,4]	1	CNS
Phenobarbital	[3]	6	CNS
Prednisone	[3,4]	6	Anti-inflammatory
Probenecid	[2]	0	Gout
Procarbazine	[3]	0	CNS
Promethazine	[1-3]	20	Antihistamine
Quinacrine	[3]	4	Antiprotozoal
Reserpine	[1-3]	2	CNS
Salicyclic acid	[3]	4	Antirheumatic
Sildenafil	[1-3]	2	Erectile dysfunction
Sirolimus	[3]	1	Immunosuppressive
Tamoxifen	[1-4]	1	Cancer
Terfenadine	[3]	1	Antihistamine
Thalidomide	[1,2]	1	Cancer
Tolazoline	[3]	0	Cardiovascular
Trimethadione	[3]	1	CNS
Zidovudine	[1,2]	5	Antiviral

CNS: Central nervous system; LSD: Lysergische säure diäthylamid (lysergic acid diethylamide).