©2012 Baishideng Publishing Group Co.
World J Clin Oncol. Jan 10, 2012; 3(1): 1-6
Published online Jan 10, 2012. doi: 10.5306/wjco.v3.i1.1
Published online Jan 10, 2012. doi: 10.5306/wjco.v3.i1.1
Table 3 List of drugs discovered to be beneficial for conditions other than for which they were developed (clinical)
| Off-label drugs | Derivatives | No. of derivatives |
| Aminoglutethimide | NA | 0 |
| Alprostadil | Dinoprostone, carboprost, tromethamine, dinoprost, tromethamine, misoprostol | 4 |
| Amphetamine | Phentermine, methamphetamine, dextroamphetamine, alverine, selegiline, mephentermine, tranylcypromine, phenelzine, benzphetamine, diethylpropion | 10 |
| Aspirin | NA | 0 |
| Auranofin | NA | 0 |
| Carbamazepine | Oxcarbazepine | 1 |
| Celecoxib | NA | 0 |
| Chlordiazepoxide | Diazepam, temazepam, oxazepam, fludiazepam, clorazepate, halazepam, prazepam, flurazepam, lorazepam, cinolazepam, clonazepam, nitrazepam, bromazepam, flunitrazepam, quazepam, clotiazepam, alprazolam, estazolam, adinazolam, midazolam | 20 |
| Chlorothiazide | Benzthiazide, diazoxide, hydrochlorothiazide, hydroflumethiazide, bendroflumethiazide, cyclothiazide, polythiazide, trichlormethiazide, methyclothiazide, furosemide, bumetanide | 11 |
| Clofibrate | Fenofibrate | 1 |
| Dactinomycin | NA | 0 |
| Diisopropylfluorophosphate | NA | 0 |
| Diltiazem | NA | 0 |
| Dimenhydrinate | NA | 0 |
| Diphenhydramine | Bromodiphenhydramine, diphenylpyraline | 2 |
| Diphenoxylate | Loperamide | 1 |
| Dipyridamole | NA | 0 |
| Disulfiram | NA | 0 |
| Doxorubicin | Epirubicin, daunorubicin, idarubicin, valrubicin, plicamycin | 5 |
| Etomidate | NA | 0 |
| Finasteride | Dutasteride | 1 |
| Guanethidine | Debrisoquin, guanidine | 2 |
| Haloperidol | Droperidol | 1 |
| Imatinib | NA | 0 |
| Imipramine | Trimipramine, desipramine, clomipramine, protriptyline, amitriptyline, nortriptyline, cyclobenzaprine, maprotiline, doxepin, amoxapine | 10 |
| Iproniazid | Isocarboxazid | 1 |
| Linezolid | NA | 0 |
| Lysergic acid diethylamide | Cabergoline, lisuride, bromocriptine, nicergoline, pergolide | 5 |
| Meprobamate | Carisoprodol | 1 |
| Mercaptopurine | Thioguanine, azathioprine | 2 |
| Metronidazole | Tinidazole | 1 |
| Mifepristone | NA | 0 |
| Minoxidil | NA | 0 |
| Mycophenolic acid | Mycophenolatemofetil | 1 |
| Naloxone | Naltrexone | 1 |
| Norethindrone | Levonorgestrel, norgestrel, etonogestrel, gestodene,desogestrel, medroxyprogesterone, megestrol, progesterone, drospirenone, norelgestromin, ethynodioldiacetate | 11 |
| Pethidine | Anileridine | 1 |
| Phenobarbital | Methylphenobarbital, secobarbital, metharbital, aprobarbital, primidone, methsuximide | 6 |
| Prednisone | Medrysone, methylprednisolone, prednisolone, rimexolone, fluocortolone, desoximetasone | 6 |
| Probenecid | NA | 0 |
| Procarbazine | NA | 0 |
| Promethazine | Acepromazine, aceprometazine, acetophenazine, arphenazine, chlorpromazine, ethopropazine, fluphenazine, mesoridazine, methotrimeprazine, perphenazine, pipotiazine, prochlorperazine, promazine, propericiazine, propiomazine, thioproperazine, thioridazine, trifluoperazine, triflupromazine, trimeprazine | 20 |
| Quinacrine | Chloroquine, primaquine, hydroxychloroquine, amodiaquine | 4 |
| Reserpine | Deserpidine, rescinnamine | 2 |
| Salicyclic acid | Salsalate, olsalazine, diflunisal, mesalazine | 4 |
| Sildenafil | Tadalafil, vardenafil | 2 |
| Sirolimus | Everolimus | 1 |
| Tamoxifen | Toremifene | 1 |
| Terfenadine | Fexofenadine | 1 |
| Thalidomide | Lenalidomide | 1 |
| Tolazoline | NA | 0 |
| Trimethadione | Paramethadione | 1 |
| Zidovudine | Trifluridine, telbivudine, idoxuridine, zalcitabine, stavudine | 5 |
- Citation: Hargrave-Thomas E, Yu B, Reynisson J. Serendipity in anticancer drug discovery. World J Clin Oncol 2012; 3(1): 1-6
- URL: https://www.wjgnet.com/2218-4333/full/v3/i1/1.htm
- DOI: https://dx.doi.org/10.5306/wjco.v3.i1.1