Editorial
Copyright ©2011 Baishideng Publishing Group Co.
World J Clin Oncol. Sep 10, 2011; 2(9): 329-338
Published online Sep 10, 2011. doi: 10.5306/wjco.v2.i9.329
Table 2 Summary of DNA lesion type, repair mechanism and gene products
Repair mechanismDNA lesion typeGenes or gene families involved in repair
NERDistortions of DNA double helix or bulky adductsXeroderma pigmentosum related genes (XPA, XPC and others) and Cockayne’s syndrome related genes (ERCC6 and others)
BERSmall, non-helix-distorting nucleotide base lesions or single strand breaksAP endonucleases, DNA glycosylases
MMRIncorrectly paired nucleotides, insertions and deletion loopsMSH2, MLH1
HRSSB and DSBBRCA1/2, BRIT1, BLM
NHEJChromosomal breaks, also to create genetic diversity for immune cellsKu70, Ku80, DNA-PKcs, XRCC4