Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations

doi:10.5306/wjco.v2.i5.195

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May 10, 2011 (publication date) through May 10, 2024

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. May 10, 2011; 2(5): 195-202
Published online May 10, 2011. doi: 10.5306/wjco.v2.i5.195

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Figure 1 Multi-step carcinogenesis hypothesis of pancreatic cancer. As genetic alterations of Kras, p16^INK4a, p53, Smad4 and BRCA2 accumulate, the pre-cancer lesion pancreatic intraepithelial neoplasia (PanIN) occurs and progresses from low-grade (1A, 1B) to high-grade (2, 3) and to invasive cancer. The frequency of each genetic alteration at the invasive cancer stage is also shown.

Citation: Ijichi H. Genetically-engineered mouse models for pancreatic cancer: Advances and current limitations. World J Clin Oncol 2011; 2(5): 195-202
URL: https://www.wjgnet.com/2218-4333/full/v2/i5/195.htm
DOI: https://dx.doi.org/10.5306/wjco.v2.i5.195