Targeting metastatic upper gastrointestinal adenocarcinomas

doi:10.5306/wjco.v2.i3.135

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World Journal of Clinical Oncology

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2218-4333

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Clin Oncol. Mar 10, 2011; 2(3): 135-149
Published online Mar 10, 2011. doi: 10.5306/wjco.v2.i3.135

Table 2 Antiangiogenic agents in upper gastrointestinal malignancies

Drug	Mechanism of action	Applicable tumor sites
Bevacizumab	Intravenous recombinant humanized monoclonal antibody against VEGF	Gastric
		Hepatocellular
		Biliary tract
		Pancreas
Sunitinib	Oral multitargeted TKI inhibiting VEGFR-1, VEGFR-2, PDGFR-β, c-KIT, FLT3, and RET	Gastric
Sunitinib		Hepatocellular
Sorafenib	Oral multitargeted TKI inhibiting VEGFR-1, VEGFR-2, PDGFR-β, Raf-1, B-Raf, and intracellular serine-threonine kinases	Gastric
		Hepatocellular
		Pancreas

VEGF: Vascular endothelial growth factor; VEGFR: Vascular endothelial growth factor receptor; TKI: Tyrosine kinase inhibitor; PDGFR: Platelet-derived growth factor receptors.

Citation: Spratlin JL, Chu Q, Koski S, King K, Mulder K. Targeting metastatic upper gastrointestinal adenocarcinomas. World J Clin Oncol 2011; 2(3): 135-149
URL: https://www.wjgnet.com/2218-4333/full/v2/i3/135.htm
DOI: https://dx.doi.org/10.5306/wjco.v2.i3.135