Locally advanced nasopharyngeal carcinoma: Current and emerging treatment strategies

Table 4 Neoadjuvant chemotherapy trials

Trial	Phase	Pts	Study design	Main end-point	Results
Al-Amro A et al[23]	II	110	Neo cDDP-Epi and followed by cDDP + RT	ORR	100%
Airoldi M et al[24]	II	30	Neo cbdca-Pac followed by RT + cbdca-Pac	ORR	87%
Ferrari D et al[25]	II	34	Neo cDDP-5FU followed by RT + cDDP	ORR	85.3%
Lu X et al[26]	II	58	Neo cbdca-Tax followed by cbdca + RT (arm A) vs neo cbdca-5FU followed by cbdca + RT (armB)	1-year DFS	no difference between arm A and B
Mosatafa E et al[27]	II	36	Neo cDDP-Pac followed by cDDP-RT	ORR	89%
Hui EP et al[28]	II	65	Neo cDDP-Tax followed by cDDP + RT (arm A) vs cDDP + RT (arm B)	3-year OS	Arm A better than arm B (P < 0.012)
Bossi P et al[29]	II	45	Neo cDDP-Tax-5FU followed by cDDP + RT	ORR	98%
Cho S et al[30]	II	19	Neo cDDP-Tax-5FU followed by cDDP + RT	ORR	93%
Bae WK et al[32]	II	33	Neo cDDP-Tax-5FU followed by cDDP + RT	ORR	99%
Kong L et al[6]	II	52	Neo cDDP-Tax-5FU followed by cDDP + RT	ORR	90.2%
Ekenel M et al[34]	II	59	Neo cDDP-Tax followed by cDDP + RT	ORR	95%
Lin S et al[35]	II	370	Neo cDDP based CT followed by IMRT	3-year OS	90%

RT: Radiotherapy; IMRT: Intensity modulated RT; CT: Comptued tomography; ORR: Overall response rate; DFS: Disease-free survival.