Locally advanced nasopharyngeal carcinoma: Current and emerging treatment strategies

Table 3 Adjuvant chemotherapy trials

Trial	Phase	Pts	Study design	Main end-point	Results
Al-Sarraf M et al[18]	III	147	Exclusive RT alone vs CCRT followed by cDDP-5FU	3-year PFS	Experimental arm better (P < 0.01)
Chen Y et al[19]	III	316	Exclusive RT alone vs CCRT followed by cDDP-5FU	2-year OS	Experimental arm better (P < 0.003)
Lee AW et al[20]	III	348	Exclusive RT alone vs CCRT followed by cDDP-5FU	5-year PFS	Experimental arm better (P < 0.035)
Park KH et al[21]	II	43	cDDP-5-FU + RT followed by cDDP-Epi-Ble CT	ORR	100%
Hu W et al[22]	II	54	w Pac + RT followed by cDDP-Pac CT	ORR	100%
Leung TW et al[10]	II	48	HFRT + cDDP based CT followed by cDDP-5FU CT	3-year DFS	71%

RT: Radiotherapy; CT: Comptued tomography; ORR: Overall response rate; CCRT: Concurrent chemoradiotherapy; DFS: Disease-free survival.